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. SEMA4D - Wikipedia. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.. SEMA4D Gene - GeneCards | SEM4D Protein | SEM4D Antibody. SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Cholangitis, Primary Sclerosing and Diffuse Glomerulonephritis.Among its related pathways are Semaphorin interactions and Nervous system development.Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transmembrane signaling receptor activity.. SEMA4D - an overview | ScienceDirect Topics. SEMA4D is the immune semaphorin that has been most strongly correlated to poor prognosis. It is induced in multiple cancers, including soft tissue carcinoma, head and neck cancer, prostate cancer, breast cancer, and colon cancer [7]

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. Moreover, in pancreatic cancer, expression of SEMA4D and its receptor Plexin B1 correlates to advanced disease .. SEMA4D/CD100, a novel target for immune-oncology

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SEMA4D is also known as CD100 because it is expressed on T-cells. It binds to CD72, which is expressed on B-cells, dendritic cells, macrophages, and mast cells. The high affinity receptor for SEM4D is also expressed on epithelial cells and endothelial cells (inducing angiogenesis and endothelial cell migration), and low-affinity receptors are .. 10507 - Gene ResultSEMA4D semaphorin 4D [ (human)]. Semaphorin 4D Induces an Imbalance of Th17/Treg Cells by Activating the Aryl Hydrocarbon Receptor in Ankylosing Spondylitis. SEMA4D under the posttranscriptional regulation of HuR and miR-4319 boosts cancer progression in esophageal squamous cell carcinoma. Signaling from membrane semaphorin 4D in T lymphocytes.. Semaphorin 4D as a guidance molecule in the immune system. Semaphorin 4D (Sema4D) is a classic member of the semaphorin family involved in axonal guidance processes

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. The key effects of Sema4D in neurons are mediated by high affinity plexin receptors and are associated with cytoskeleton rearrangement, leading to growth cone collapse or regulation of cell migration

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. Pierre Semard - Wikipedia. Pierre Semard (15 February 1887 - 7 March 1942) was a trade unionist, secretary general of the federation of railway-workers and leader of the French Communist Party (acting as its secretary general from 1924 to 1928)

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